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Hi there, I am seeing four signals at equal height between -0.6 and 0.5 PPM of a 1H NMR sample in dmso-d6. The reaction involves a reductive amination of a heterocylic aldehyde and a primary amine with NaCNBH3. Any thoughts.., appreciated.

asked May 20 '14 at 02:54

TBS's gravatar image


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The BH3 group of cyanoborohydride resonates in this region of the proton spectrum and appears as a 1:1:1:1 quartet to due to 11B coupling. See Li and London, Biotechnology Letters, 28, 623-629, 2002 for a reference.


answered May 23 '14 at 13:02

Eugene%20DeRose's gravatar image

Eugene DeRose

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