On our Avance III 500 we use Topshim quite successfully for any probe with a gradient coil. The only time we have a problem is with CDCl3 solvent on our 1.7 mm TXI probe, where Topshim fails with a complaint about the signal to noise ratio being too low. This is not surprising for a microprobe, as CDCl3 has the lowest signal of any common deuterated solvent. We have confirmed that the 2H pulse length is correct in the prosol file.

An obvious solution would be to increase the nunber of scans for this probe/solvent combination. There seem to be probe and solvent specific parameter files in the topshim folder (under ..\conf\instr). I have tried making some changes to these files in the obvious places, but the number of scans used always seems to remain at the default (4 for 2H).

Does anyone know how to do this properly?

Thanks

-Kirk

On our Avance III 500 we use Topshim quite successfully for any probe with a gradient coil. The only time we have a problem is with CDCl3 solvent on our 1.7 mm TXI probe, where Topshim fails with a complaint about the signal to noise ratio being too low. This is not surprising for a microprobe, as CDCl3 has the lowest signal of any common deuterated solvent. We have confirmed that the 2H pulse length is correct in the prosol file.

An obvious solution would be to increase the nunber of scans for this probe/solvent combination. There seem to be probe and solvent specific parameter files in the topshim folder (under ..\conf\instr). I have tried making some changes to these files in the obvious places, but the number of scans used always seems to remain at the default (4 for 2H).

Does anyone know how to do this properly?properly? Clemens, I'm looking at you :-)

Thanks

-Kirk

On our Avance III 500 we use Topshim quite successfully for any probe with a gradient coil. The only time we have a problem is with CDCl3 solvent on our 1.7 mm TXI probe, where Topshim fails with a complaint about the signal to noise ratio being too low. This is not surprising for a microprobe, as CDCl3 has the lowest signal of any common deuterated solvent. We have confirmed that the 2H pulse length is correct in the prosol file.

An obvious solution would be to increase the nunber of scans for this probe/solvent combination. There seem to be probe and solvent specific parameter files in the topshim folder (under ..\conf\instr). I have tried making some changes to these files in the obvious places, but the number of scans used always seems to remain at the default (4 for 2H).

Does anyone know how to do this properly?

Clemens, I'm looking at you :-)

Thanks

-Kirk