You may modify a 'standard' 2D HSQC pulse sequence, such that the 180 proton pulse in the middle of the 13C evolution period is preceded by a 180 pulse that is selective for the proton's that are coupling to the carbon of interest. This would be equivalent to a 360 pulse for the proton of interest, leaving the remaining unchanged. Alternately, a shaped pulse specifically designed for inversion of all proton peaks other than the peak of interest may be used to replace the 'hard' 180 proton pulse in the middle of the 13C evolution period of HSQC.

These methods will work only if the chemical shifts of the proton/s coupling to the carbon of interest are well resolved from those of the remaining protons.

You may modify a 'standard' 2D HSQC pulse sequence, such that the 180 proton pulse in the middle of the 13C evolution period is preceded by a soft/shaped 180 pulse that is selective for the proton's that are coupling to the carbon of interest. This would be equivalent to a 360 pulse for the proton of interest, leaving the remaining unchanged. Alternately, a shaped pulse specifically designed for inversion of all proton peaks other than the peak of interest may be used to replace the 'hard' 180 proton pulse in the middle of the 13C evolution period of HSQC.

These methods will work only if the chemical shifts of the proton/s coupling to the carbon of interest are well resolved from those of the remaining protons.