In principle it should work as well. Please, check: 1. D8 (mixing time) 2. Edprosol and check shaped pulses and their power 3. Gradient values 4. If probe is tuned and matched 5. This is essential: check that you properly set O1 and SR equals to 0, sometimes when one creates experiment from proton with calibrated scale non-zero SR plus measured center of peak would lead to wrong O1.

Assuming that all of your pulses (both the hard pulses and shaped pulses) and everything else are calibrated properly, it could be that at 600 MHz you are now at the cross-over point between extreme narrowing and spin-diffusion. What is the molecular weight of your compound, and what solvent are you using?

The easiest way to set up these experiemnts is with the selective panel, available from the "Spectrometer" menu. This will only work if you have a properly setup prosol table, however.

If you are at the cross-over point, a ROESY experiment may work.

Do you see the signal from the selected peak and nothing else, or do you see nothing at all? If it's just that the NOE is zero under your conditions on the 600, then you should at least see the inverted peak, with reasonable intensity (you will lose some signal due to relaxation during the selective pulse and mixing time).

You could also run the simple selective gradient spin echo pulse program selgpse - just copy the dataset used for the selective noesy and change the pulse program. If that doesn't give a decent signal, then likely there is a problem with the setup of the selective step.